Cicci JD, Reed BN, McNeely EB et al. Acute decompensated heart failure: evolving literature and implications for future practice. Pharmacotherapy. May interfere with the fluorescent measurement of quinidine serum levels. May decrease serum protein-bound iodine levels without signs of thyroid disturbance. Take this medication by mouth as directed by your doctor, usually once daily in the morning with or without food. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate. The Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA.
UpToDate: “Patient information: Cirrhosis Beyond the basics. PREGNANCY and BREAST-FEEDING: It is not known if triamterene can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using triamterene while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking triamterene. Tacrolimus Systemic: Potassium-Sparing Diuretics may enhance the hyperkalemic effect of Tacrolimus Systemic. Risk of electrolyte imbalance and renal dysfunction may be increased when triamterene 75 mg daily with hydrochlorothiazide 50 mg daily is administered in 2 divided doses rather than 1 daily dose.
Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Reducing the dose of this drug may be necessary in the presence of electrolyte imbalance and in geriatric patients. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; burning, numbness, or tingling; confusion; decreased urination; drowsiness; dry mouth; excessive thirst; eye pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; mental or mood changes; muscle cramps, pain, or weakness; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dizziness; shortness or breath; sluggishness; stomach pain; symptoms of high blood sugar eg, increased thirst, hunger, or urination; drowsiness; flushing; rapid breathing; fruit-like breath odor; tiredness or weakness; tremor; unusual bruising or bleeding; vision changes eg, decreased vision clearness; vomiting; yellowing of the skin or eyes.
Primarily metabolized to 6- p-hydroxytriamterene and its sulfate conjugate. Talk to your doctor or about lifestyle changes that might benefit you. This is not a complete list of possible side effects. If you notice other side effects not listed above, contact your doctor or pharmacist. The DASH-Sodium study shows the importance of lowering sodium intake whatever your diet. But for a true winning combination, follow the DASH eating plan and lower your intake of salt and sodium.
Dizziness, lightheadedness, headache, or upset stomach may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. IV: If needed, repeat dose in 2 hours, after another 2 hours increase dose by 20 to 40 mg until an adequate diuresis. This dose should then be given once or twice a day. Hypersensitivity to the drug or any of its components. Twice-daily administration of the fixed combination of triamterene and hydrochlorothiazide may increase risk of electrolyte imbalance and renal dysfunction. Adrenal insufficiency: Avoid use of diuretics for treatment of elevated blood pressure in patients with primary adrenal insufficiency Addison disease. Use with caution in patients with impaired hepatic function. a Do not use in patients with severe hepatic disease. a Diuretic therapy in such patients should be initiated while the patient is hospitalized, because rapid alterations in fluid and electrolyte balance may precipitate hepatic coma. a Monitor serum potassium concentrations closely in patients with hepatic cirrhosis and administer potassium supplementation if required. a See Contraindications under Cautions. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Diabetes patients - Maxzide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Symptoms may include decreased or excessive urination; fainting; fever; flushed face; light-headedness, especially when standing; nausea; severe dizziness; vomiting; weakness. Back to taking 2 halves a day --every 12 hours --so I sleep without interruption! Maximum recommended by manufacturer: 300 mg daily. Bertek. Maxzide and Maxzide -25 mg tablets prescribing information. Sugar Land, TX; 2002 Dec. Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. This product may cause your body to lose too much water and salt dehydration. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine.
Contact your doctor or health care provider right away if any of these apply to you. Triposkiadis FK, Butler J, Karayannis G et al. Efficacy and safety of high dose versus low dose furosemide with or without dopamine infusion: the Dopamine in Acute Decompensated Heart Failure II DAD-HF II trial. Int J Cardiol. Maxzide is a diuretic water pill and is a combination of a potassium-sparing diuretic triamterene and a thiazide diuretic hydrochlorothiazide. It works by making the kidneys eliminate sodium salt and water from the body, which helps to lower blood pressure. The triamterene component helps minimize potassium loss. GlaxoSmithKline. Dyazide capsules prescribing information. Philadelphia, PA; 1999 Feb. Do not start, stop, or change the dosage of any medicines without your doctor's approval. UpToDate: “Patient information: Deep vein thrombosis Beyond the basics. May result in severely elevated serum potassium levels. Following cardiac surgery, a continuous infusion is as effective as intermittent boluses of furosemide. Total daily urine output and change in serum electrolyte levels were similar between the two methods of administration. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; dry mouth; excessive thirst; slow or irregular heart rate; unusual muscle weakness; unusual tiredness; vomiting; yellowing of the skin or eyes. Orthostatic or general hypotension, tachycardia, syncope, electrolyte abnormalities, potassium deficiency, vomiting, nausea, shock, weakness, confusion, dizziness, cramps of calf muscles, thirst, polyuria, anuria, lethargy. The opinions expressed in WebMD Second Opinion are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD Second Opinion are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents.
Dosage is based on your medical condition and response to treatment. Lately you've been feeling a little -- to put it delicately -- backed up. You're not "going" as often as you should, and you feel bloated and uncomfortable. Ask your doctor if your meds may be the problem. If so, there may be something else you can take instead. Reserve laxatives for constipation that doesn't improve after you've added fiber and water to your diet. FL 34243 USA, By WellSpring Pharmaceutical Canada Corp. Your condition will not improve any faster, and your risk of side effects will increase.
Most people get enough potassium by eating a well-. GFR or a depletion of the intravascular fluid volume. d May occur more frequently in patients receiving twice-daily dosing with fixed combination of triamterene and hydrochlorothiazide. Consult your doctor before breast-feeding. Doses greater than 200 mg are rarely needed for treatment of edema. National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC VI. Bethesda, MD: National Institutes of Health. NIH publication No. 98-4080. Potassium excretion usually reduced; serum concentrations of potassium and chloride are usually increased. Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. IV: 20 to 100 mg every 1 to 2 hours over 1 to 2 minutes.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, high level of potassium in the blood, kidney disease including kidney stones liver disease, lupus. Edema: For the treatment of edema associated with congestive heart failure, cirrhosis of the liver and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema and edema due to secondary hyperaldosteronism. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Some medical conditions may interact with triamterene. In patients who develop hyperkalemia or if hyperkalemia is suspected, obtain an electrocardiogram to rule out hyperkalemia-induced QRS prolongation or other cardiac arrhythmias. Discontinue triamterene and any potassium supplementation in patients who develop hyperkalemia; treat cardiac arrhythmias as clinically indicated. Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor. IM or IV: Note: Significant absorption within Extracorporeal Membrane Oxygenation ECMO circuit; avoid administration directly into circuit; high doses may be required for adequate diuretic effect. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Tell your doctor if you develop any new symptoms. Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Triamterene may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use triamterene with caution. Diacerein: May enhance the therapeutic effect of Diuretics. Specifically, the risk for dehydration or hypokalemia may be increased. It is sparingly soluble in methanol. UpToDate: “Patient information: Low-sodium diet Beyond the basics. Here are a few effective constipation treatments. Continued Could it be a heart problem?
Do not exceed 300 mg daily. Dofetilide: Triamterene may increase the serum concentration of Dofetilide. Diuretic-induced hypokalemia and hypomagnesemia may precipitate digitalis-induced arrhythmias. This medication should not be used if you have certain medical conditions. Management of edema associated with heart failure, cirrhosis of the liver, or nephrotic syndrome. Angiotensin II Receptor Blockers: May enhance the hyperkalemic effect of Potassium-Sparing Diuretics. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. If you have diabetes, this product may affect your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or a serious loss of body water dehydration. Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise. Nicorandil: May enhance the hyperkalemic effect of Potassium-Sparing Diuretics. Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Blocks epithelial sodium channels in the late distal convoluted tubule DCT and collecting duct which inhibits sodium reabsorption from the lumen.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. The key is to keep blood circulating. If you stand or sit all day, it's important to take time to move around. Could it be hormones? Diarrhea; headache; loss of appetite; nausea; weakness. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Do not use concurrent potassium supplementation or potassium-containing salt substitutes. b Discontinue potassium supplementation when triamterene is added to other diuretic therapy or when patients are switched to triamterene from other diuretics. Herbs Hypotensive Properties: May enhance the hypotensive effect of Blood Pressure Lowering Agents. This medication contains sodium. The top number, which is the systolic blood pressure, corresponds to the pressure in the arteries as the heart contracts and pumps blood into the arteries. The bottom number, the diastolic pressure, represents the pressure in the arteries as the heart relaxes after the contraction. The diastolic pressure reflects the lowest pressure to which the arteries are exposed. Maxzide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
Do not crush, chew, or suck extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or tells you to do so. Swallow the whole or split tablet without crushing or chewing. Senekot, make the muscles in your intestines contract to help push stool out. Take this medication as prescribed. Do not increase your dose or take this more often without your doctor's approval. Some MEDICINES MAY INTERACT with Maxzide. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics.
Heparin: May enhance the hyperkalemic effect of Potassium-Sparing Diuretics. Management: Monitor serum potassium concentrations closely. The spironolactone Canadian product monograph lists its combination with heparin or low molecular weight heparins as contraindicated. Yancy CW. The Uncertainty of Sodium Restriction in Heart Failure: We Can Do Better Than This. JACC Heart Fail. Triamterene appears in animal milk and is likely present in human milk. Check with your pharmacist about how to dispose of unused medicine. Check your pressure regularly and tell your doctor if the results are high. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Severe hepatic disease: Use is contraindicated. Swallow the capsules whole. If you have trouble swallowing the capsules, tell your doctor or pharmacist. Some brands may be opened and the contents sprinkled onto a spoonful of cool, soft food such as applesauce or pudding. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Tell your doctor or dentist that you take triamterene before you receive any medical or dental care, emergency care, or surgery. Torres-Courchoud I, Chen HH. Is there still a role for low-dose dopamine use in acute heart failure? The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.
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Herbs Hypertensive Properties: May diminish the antihypertensive effect of Antihypertensive Agents. ATPase, leading to potassium retention and decreased calcium, magnesium, and hydrogen excretion. Brimonidine Topical: May enhance the hypotensive effect of Blood Pressure Lowering Agents.
Triamterene should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. Potassium-sparing diuretic; pteridine derivative. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with not feel sick. Gout: May cause elevation in uric acid.
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. Stachenfeld, N. Exercise and sport sciences reviews, 2008. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Some products that may interact with this drug include: dofetilide, lithium, other drugs that may increase potassium levels such as spironolactone, amiloride, cyclosporine. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Triamterene is a weak folic acid antagonist and may contribute to megaloblastosis.